UK Clinical Pharmacy Association

Mebeverine

Issues for surgery

For irritable bowel syndrome, smooth muscle spasm, dysmenorrhoea – loss of symptomatic relief if omitted.

Advice in the perioperative period

Elective and emergency surgery 

Continue.

Except:

  • Fybogel mebeverine® (ispaghula + mebeverine)

Post-operative advice

Resume post-operatively, if needed, once enteral intake resumed.

Review alverine citrate and mebeverine if patient develops reduced gastrointestinal motility (e.g. ileus) post-operatively.

Interactions with common anaesthetic agents

None.

Interactions with other common medicines used in the perioperative period

None.

Further information

None relevant.

References

Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 7th March 2021]

Summary of Product Characteristics – Spasmonal® (alverine citrate) 60mg Hard Capsules. Mylan. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text February 2018]

Summary of Product Characteristics – Mebeverine 135mg film-coated tablets. Aurobindo Pharma-Milpharm Ltd. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text October 2020]

Summary of Product Characteristics – Colpermin® (peppermint oil) IBS Relief Capsules. McNeil Products Ltd. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text October 2020]

Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press.