Issues for surgery
Deterioration in cognitive function if omitted.
Advice in the perioperative period
Elective and emergency surgery
Continue.
Interactions with common anaesthetic agents
Esketamine and ketamine
Concurrent use of memantine and esketamine/ketamine should be avoided. Both medicines are N-methyl-D-aspartate (NMDA) antagonists and potentially concurrent use could increase the frequency and severity of central nervous system adverse drug reactions including psychosis.
Interactions with other common medicines used in the perioperative period
None.
Further information
None relevant.
References
Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 10th May 2019]
Summary of Product Characteristics – Ebixa® (memantine). Lundbeck limited. Accessed via www.medicines.org.uk 10/05/2019 [date of revision of the text October 2016]
Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 10th May 2019]