Issues for surgery
Loss of control of spasticity if omitted.
Advice in the perioperative period
Elective and emergency surgery
Continue.
Post-operative advice
Restart post-operatively when enteral intake resumes and next dose due, manufacturer recommends tablets should be taken with sufficient fluid (e.g. a glass of water) and swallowed whole.
Review if patient develops reduced gastrointestinal obstruction post-operatively.
Interactions with common anaesthetic agents
Antimuscarinic action
Antimuscarinic action of pridinol may be additive with agents that also have antimuscarinic effects such as atropine and glycopyronnium.
Interactions with other common medicines used in the perioperative period
Antimuscarinic action
Antiemetics
Antimuscarinic action of pridinol may be additive with antiemetics that also have antimuscarinic effects such as cyclizine, haloperidol, levomepromazine or prochlorperazine.
Nefopam
Antimuscarinic action of pridinol may be additive with nefopam which also has antimuscarinic effects.
Further information
None relevant
References
Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 28th May 2024]
Summary of Product Characteristics – Myopridin® (pridinol) 3mg tablets. Mibe Pharm UK Limited. Accessed via https://products.mhra.gov.uk 28/05/2024 [date of revision of the text March 2023]