UK Clinical Pharmacy Association


Issues for surgery

Loss of symptomatic relief of allergic rhinitis, hay fever and urticaria if omitted.

Advice in the perioperative period

Elective and emergency surgery


Post-operative advice

If taken regularly, restart post-operatively as soon as next dose is due; otherwise restart when symptoms develop.

Interactions with common anaesthetic agents


Interactions with other common medicines used in the perioperative period


Clarithromycin and erythromycin are predicted to increase the exposure rupatadine through inhibition of CYP3A4. Concomitant use of clarithromycin is contraindicated by the manufacturers of rupatadine, whilst concomitant use of erythromycin is cautioned.

Whilst single surgical prophylactic doses should not pose a problem in patients taking bilastine, monitor for side effects if a prolonged course is required.

Further information

None relevant. 


Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press. [Accessed on 2nd February 2021] 

Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. [Accessed on 2nd February 2021]

Summary of Product Characteristics – Rupatadine 10mg Tablets. Aspire Pharma Ltd. Accessed via 2/2/2021 [date of revision of the text September 2020]